Whole Blood Histamine

Histamine is a biologically active amine involved in immune responses, gut regulation, and also functions as a neurotransmitter. Imbalances in histamine levels have been associated with conditions such as allergies, schizophrenia, depression, anxiety, behavioral disorders, and autism spectrum disorders. 
While histamine is most commonly recognized for its role in allergic reactions, it also acts as a neurotransmitter, similar to serotonin and dopamine. In addition, histamine plays a role in regulating the sleep-wake cycle, aligning the biological clock and circadian rhythms. It is also involved in appetite regulation, neurotransmission, and pain perception.

Effects of Histamine on the Body

Elevated whole blood histamine levels indicate undermethylation. Emotional and behavioral traits may reflect histamine imbalance. Individuals with undermethylation often experience seasonal allergies, tend to be perfectionists, may have obsessive-compulsive tendencies, and are more likely to exhibit depressive mood patterns. 
Low whole blood histamine levels suggest overmethylation. People with overmethylation typically show signs of high anxiety, may be prone to panic disorders, often display strong artistic or musical abilities, and tend to have increased sensitivity or adverse reactions to SSRIs such as Prozac.

Histamine Imbalance 
Histamine imbalance is associated with undermethylation and may contribute to the development of the following conditions or symptoms

Histamine Imbalance
Depression	Anxiety
Anorexia	Schizophrenia
ADHD	Autism
Obsessive-Compulsive Disorder (OCD)	Bipolar Disorder

The important information provided by Whole Blood Histamine Analysis is as follows

• Whole blood histamine levels are used as biomarkers of methylation status and help determine the presence of conditions such as histadelia or histapenia. They serve as accurate indicators of undermethylation or overmethylation.
• Low histamine levels are commonly observed in individuals with depression, anxiety, and related disorders. In contrast, elevated histamine levels have been found in patients with schizophrenia, obsessive-compulsive disorder (OCD), anorexia nervosa, and autism spectrum disorder. High histamine is also linked to allergies and immune-related physiological responses.
• Histamine levels should be interpreted in conjunction with methylation metabolism, as their relationship is closely connected. This combined analysis can help physicians develop personalized health management plans, incorporating amino acids, trace elements, and other nutrients to support and improve the methylation cycle.