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Functional Medicine Testing

FUNCTIONAL MEDICINE TESTING INFORMATION

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1295 TruAge COMPLETE

The Comprehensive Biological Age Assessment utilizes the world’s most advanced and proprietary OMICmAge algorithm, which calculates biological (physiological) age by analyzing DNA methylation patterns at nearly one million sites associated with chronological age. 
While aging is often viewed as a symptom of disease, it is in fact a major underlying factor in disease development. Biological aging is the number one risk factor for all chronic diseases, which are the leading causes of death in developed countries. Many common diseases—such as type 2 diabetes, cardiovascular diseases, and cancer—are strongly influenced by the aging process. 
Assessing biological age enables physicians to focus on prevention and early intervention for age-related diseases, even before symptoms appear.

Testing Content

TrueAge
TrueAge testing is an epigenetic test that analyzes changes in your DNA to determine how these changes are actually impacting your health. This innovative epigenetic analysis uses specific markers on your DNA called methylation to estimate your biological age. 
Biological age is a strong predictor of healthspan, and this technology is more accurate than any previous molecular biomarker. It can also be linked to a variety of age-related diseases, such as Alzheimer’s disease and cancer. 
Ideally, everyone hopes their biological age is lower than their chronological age, which would indicate a healthy lifestyle that helps reduce the risk of disease and supports longer-lasting health.


DunedinPACE
It is possible to quantify a person’s rate of aging and biological age dynamically, much like a real-time aging speedometer, rather than only assessing their current age at fixed points in time. Biological age is a valuable metric, but it does not capture how past history and current lifestyle have influenced the epigenome over time. By combining biological age measurement (OMICmAge) with real-time aging rate assessment (DunedinPACE), we can gain deeper insights into the aging process and disease risk prediction. Integrating these two metrics offers a more comprehensive approach to preventive health management.


Telomere
Telomeres are sequences of repetitive DNA located at the ends of chromosomes. They act like protective caps that prevent chromosome damage during cell replication and division. Under normal physiological conditions, telomere length (measured in base pairs, bp) gradually shortens with each cell division. When telomeres become too short, they lose their protective function, leading to cellular senescence or apoptosis. This is a natural part of the aging process.
However, shorter telomeres may indicate that the body has been under chronic inflammation and oxidative stress for an extended period. This is associated with an increased risk of various chronic diseases, including cardiovascular disease, metabolic disorders, lung disease, weakened immunity, and neurodegenerative conditions.


Mitotic Clock
Cells replicate through a process called mitosis, during which DNA is fully duplicated as the cell divides. This process is essential for our survival, as cell replication is crucial for the growth, healing, and repair of our tissues.


Potential Symptoms and Disease Risks of Biological Aging
Cardiovascular diseaseInsulin resistance
Diabetes mellitusAging
AsthmaRulmonary fibrosis
Cognitive declineAlzheimer's disease
DepressionOsteoporosis

The important information provided by TruAge COMPLETE is as follows

  • Measure Biological Age with the Latest OMICmAge Technology
    Your physical function and health performance are not solely determined by your DNA. Key factors that influence biological age include your epigenome and transcriptome, peptides and proteomics within your body, as well as metabolites resulting from developmental processes and environmental exposures. This interconnected cellular roadmap is referred to as multi-omics, which encompasses the various layers of physiological age measurement across the body.
  • Assess Aging Level and Chronic Disease Risk
    Accelerated aging (when biological age exceeds chronological age) increases your risk of developing diseases each year. Conversely, a younger biological age is associated with reduced risk. Increases or decreases in OMICmAge are linked to changes in the risk of mortality, cancer, heart disease, stroke, diabetes, COPD, and depression.
  • Evaluate Yearly Aging Pace and Potential Risks
    DunedinPACE reveals how many biological years you age per calendar year. A faster pace of aging is the cumulative methylation result of lifelong stress, and it correlates with higher rates of chronic diseases and mortality.
  • Measure Telomere Length and Relative Aging Risk
    Telomere length is compared to that of others in the same age group to assess your physiological aging status. Telomeres naturally shorten with age, but chronic inflammation and oxidative stress can accelerate this process, leading to premature aging of the body.
  • Test Immune Function and Assess Immunosenescence Risk
    By analyzing DNA methylation modules, we can examine various immune cells and their concentrations and how they influence biological age. The ability of immune cells to respond effectively to internal and external health threats declines with age—a phenomenon known as immunosenescence.
  • Analyze Lifestyle Impact on Physiological Aging
    Using specific DNA methylation markers, we evaluate how factors like dieting and weight loss efficiency, diabetes risk, smoking, and alcohol consumption impact biological age and the acceleration of aging.