What is a gene variant?

Among all human DNA sequences, about 99% are identical from person to person. However, a small portion of the genetic sequence varies between individuals—and these small differences can be very important to human health. These subtle changes in the DNA sequence are called polymorphisms, and they can alter the shape or function of proteins, potentially affecting normal bodily functions. As a result, they may make you more susceptible to certain diseases—or, in some cases, more resistant.
If you carry a gene variant, it may increase your risk of developing certain chronic diseases, but it does not mean you will definitely get the disease. This is because your gene expression is not fixed—it can be influenced by many factors including environmental toxins, stress, sleep, exercise, diet, alcohol consumption, education level, and even personal relationships and romantic involvement.

Detox Genomics^®

• NQO1 helps detoxify benzene and quinone derivatives. Individuals with certain polymorphisms in this gene may have an increased risk of cancer when exposed to these compounds.
• CYP1A1 plays a key role in metabolizing polycyclic aromatic hydrocarbons (PAHs). Genetic polymorphisms in CYP1A1 can raise the risk of toxic exposure and increase the likelihood of developing lung cancer and other cancers.
• GSTM1 and GSTT1 are crucial enzymes in the liver’s phase II detoxification process. They help eliminate various water-soluble toxins such as solvents, herbicides, fungicides, and heavy metals (e.g., mercury, cadmium, lead). A deletion (null variant) in these genes can increase the risk of chronic fatigue syndrome and cancer.

Important insights provided by Genomics^® include

• Understanding your inherent susceptibility
  Specific genetic polymorphisms may influence your risk for certain diseases.
• Macular Genomics^® 
  The macula is located at the central part of the retina and is responsible for the sharpest vision. Analyzing variations in the CFH gene can help in the early prevention of macular degeneration.
• Risk reduction
  With tailored recommendations on diet, environment, lifestyle habits, nutritional supplements, and medical support, you can optimize your genetic potential for better health outcomes.
• Follow-up evaluation
  Based on potential biochemical imbalances and clinical needs, additional follow-up testing can be recommended for ongoing health monitoring.