Mucosal Permeability 
Decreased intestinal permeability implies poor nutrient absorption, which may lead to malnutrition and impaired health development. In certain conditions such as gluten-sensitive enteropathy (celiac disease), the permeability to large molecules may increase, while absorption of small molecules decreases due to intestinal villi damage. 
Under such circumstances, the body's ability to rely on nutrients to support the liver’s detoxification of large antigenic molecules is significantly compromised. Therefore, repairing the intestinal mucosa is a critical step in maintaining overall gut health. 
On the other hand, studies have shown that individuals with conditions such as ankylosing spondylitis, rheumatoid arthritis, and vasculitis tend to exhibit increased intestinal permeability, which may be a contributing factor in the pathogenesis of these diseases.

Causes of Increased Intestinal Permeability

• Intestinal infection
• Ingestion of allergenic foods or toxic chemicals
• Lack of intestinal mucosal secretion of sIgA
• Trauma and endotoxemia
• Non-steroidal anti-inflammatory drugs (NSAIDs)

Increased Small Intestinal Permeability can Lead to

• More foreign substances (allergens, environmental toxins) penetrating into the bloodstream.
• Bacterial antigens interacting with tissues and organs, leading to autoimmune phenomena.
• A large influx of toxic substances into the body, overloading the liver’s detoxification system and causing excessive immune system response.

Diseases Associated with Increased Small Intestinal Permeability

• IBD
• Inflammatory joint disease
• Food allergy
• Chronic dermatologic conditions

The important information provided by Intestinal Permeability Analysis is as follows

• Chronic intestinal permeability can lead to increased exposure of intestinal antigens related to food allergies and autoimmune diseases, such as rheumatoid arthritis, ankylosing spondylitis, thyroid diseases, and myasthenia gravis.
• Impaired small intestinal permeability is associated with dysbiosis (imbalance of gut microbiota), and increased permeability can overload the liver’s detoxification system.
• Malabsorption in the intestines can result in depletion of nutrients and hindered health development.
• Chronic inflammatory bowel diseases, dysbiosis, NSAIDs, alcohol, food allergies, or oxidative stress can all induce damage to the intestinal barrier function.
• Potential recurrent Crohn’s disease or ulcerative colitis patients typically do not show symptoms.