Estrogen metabolism assessment involves measuring the levels of estrogen metabolites in urine, including phase I hydroxylation metabolites and phase II methylation metabolites.

Estrogen Metabolites	Balance of Phase I Hydroxylated Metabolites	Balance of Phase II Methylated Estrogen Metabolites
2-Hydroxyestrone 4-Hydroxyestrone 16α-Hydroxyestrone 2-Methyoxyestrone	2-Hydroxyestrone / 16α-Hydroxyestrone Ratio 2-OHE1/16α-OHE1 Ratio	2-Methoxyestrone to 2-Hydroxyestrone Ratio 2-MeOE1/2-OHE1 Ratio

Estrogen metabolism is primarily carried out by the liver in two phases: 

Phase I

Hydroxylation In this phase, estrogen undergoes hydroxylation reactions catalyzed by cytochrome P450 enzymes, resulting in hydroxylated metabolites such as 2-hydroxyestrone and 4-hydroxyestrone.

Phase II

Conjugation The hydroxylated metabolites are further metabolized through conjugation reactions, including：

Methylation   

Methyl groups are added to the metabolites, forming methylated estrogens.

Glucuronidation;  

Glucuronic acid is attached to the metabolites, increasing their water solubility.

Sulfation   

Sulfate groups are added, forming sulfate conjugates.

Glutathione Conjugation  

Glutathione is conjugated to the metabolites, facilitating their excretion. These conjugated metabolites are then excreted from the body through urine and feces.

 

 

Estrogen-META® disorders can easily lead to
anxiety/irritability	menorrhagia
endometriosis	premenstrual syndrome
menopausal Symptoms	osteoporosis
polycystic ovarian syndrome	head and neck cancers
pre-eclampsia	uterine fibroids
uterine cancers	cervical cancer
ovarian cancer	breast cancer
prostate cancer

 

 

The important information provided by Estrogen-META^® is as follows

• Understanding Estrogen Detoxification 

  Assessing whether estrogen detoxification pathways are functioning properly helps determine if estrogen metabolites are balanced. Balanced estrogen metabolism can have protective effects, while imbalances may increase the risk of conditions such as breast cancer, uterine fibroids, osteoporosis, and prostate cancer.

• The Role of Methylation in Estrogen Metabolism 

  Methylation is a key step in estrogen metabolism. It protects 2-hydroxyestrone (2-OHE1) and facilitates the metabolism of 4-hydroxyestrone (4-OHE1). Effective methylation helps eliminate carcinogenic estrogen metabolites and activates protective hormones to counteract cancer.

• Analyzing Estrogen Metabolism and Metabolites

  Analyzing estrogen metabolism and metabolites deepens our understanding of hormone excess or deficiency, aiding in the selection of personalized bioidentical hormone therapy and monitoring its effectiveness and safety, as well as developing personalized health plans.

• Further Treatment Options

  Subsequent treatments may include estrogen metabolism genetic analysis (Estro Genomics) to understand genetic constitutions (genotype) and modify environmental expressions (phenotype) that may affect estrogen metabolism.