What is bone metabolism?

Bone is a living tissue composed of cells embedded within a mineralized matrix. Throughout a person’s life, the skeleton undergoes continuous “renewal,” a process known as bone remodeling. This ongoing cycle not only repairs micro-damage but also helps maintain the mechanical integrity of the bones, enabling them to withstand stress. In fact, the human skeleton is completely renewed approximately every twelve years.
From childhood through the early twenties, bones continue to grow, as the formation of new bone exceeds bone loss. Around the age of thirty, bone mass and density reach their peak. After the age of thirty-five, however, the formation of new bone can no longer keep pace with bone resorption, leading to a gradual decline in bone density.

Osteoporosis

There are two key types of cells in human bone: osteoclasts, which break down bone tissue and release calcium into the bloodstream, and osteoblasts, which continuously build new bone and increase bone density. Before the age of forty, the activity of these two cell types is generally in balance. However, after the age of forty, both osteoclast and osteoblast functions begin to decline—with the decline in osteoblast activity being significantly greater. As a result, bone loss occurs, leading to a weakened bone structure. This condition is known as osteoporosis.

What are the symptoms of osteoporosis?

Osteoporosis is more severe in women, especially after menopause, when bone loss becomes more pronounced. However, the process of osteoporosis often occurs without any warning signs or symptoms, so patients usually only become aware of bone abnormalities after experiencing back pain or even fractures. For this reason, osteoporosis is often referred to as the silent "invisible killer." Osteoporosis most commonly leads to fractures in areas such as the spine, femoral neck, and wrist.

Bone-META® can be analyzed
Autoimmune disease	Depression
Seasonal affective disorder, SAD	Cancer
Osteoporosis	Osteomalacia
Periodontal disease	Rickets
Secondary hyperparathyroidism	Increased insulin resistance and risk of metabolic syndrome
Calcification of arteries and other soft tissues.	Parathyroid hormone, PTH & calcitonin

The important information provided by Bone-META^® is as follows

• Bone metabolism marker analysis is conducted through the assessment of bone formation markers such as osteocalcin, parathyroid hormone, bone resorption markers, and essential nutrients like vitamin D and blood calcium. This comprehensive analysis helps understand the balance between bone destruction and formation, enabling the evaluation of bone growth or osteoporosis conditions. It allows physicians to determine the appropriate clinical treatments or nutritional supplementation plans to effectively maintain bone health.
• Both excess and deficiency of vitamin D in the body can have adverse effects on health. Excessive storage can increase the risk of blood clots, while insufficient levels combined with bone loss can raise the risk of osteoporosis and fractures.

• Analyzing vitamin D can help understand

  1. Toxicity Check: You may be experiencing vitamin D toxicity due to excessive supplementation, which can lead to vascular calcification and hypervitaminosis D.

  2. Deficiency Check: Vitamin D regulates calcium and phosphorus absorption/reabsorption, which is essential for maintaining bone health.

     ．In recent years, vitamin D deficiency and insufficiency have become quite common, affecting approximately 40% of the population.
     ．Vitamin D deficiency is associated with depression and seasonal affective disorder (SAD).

  3. Neurological Role: Vitamin D plays a significant role in the autoimmune processes of the nervous system, particularly in multiple sclerosis (MS).
  4. Apoptosis Regulation: Vitamin D helps regulate the body's apoptosis (programmed cell death) mechanisms.
  5. Chronic Disease Risk: Low vitamin D levels are associated with a higher risk of heart disease, various types of cancer, and autoimmune disorders.