Histamine is a biologically active amine that plays a key role in immune responses, regulates gastrointestinal function, and acts as a neurotransmitter. Imbalances in histamine levels have been associated with allergies, schizophrenia, depression, anxiety, behavioral disorders, and autism. While histamine is most commonly discussed in the context of allergic reactions, it is also considered a neurotransmitter similar to serotonin and dopamine. Additionally, histamine is involved in regulating the sleep cycle, helping to control the biological clock and circadian rhythm. It also influences appetite regulation, interacts with other neurotransmitters, and contributes to the perception of pain.

Possible Symptoms of Histamine Intolerance Include
Asthma	Bloating
Fatigue	Flushing
Hypotension	Diarrhoea
Dysmenorrhea	Eczema
Headaches	Tachycardia

The accumulation of histamine may trigger the symptoms mentioned above, many of which closely resemble allergic reactions. Understandably, these initial symptoms are often mistaken for allergies; however, once allergies are ruled out, histamine intolerance may be identified as the underlying issue.

Foods That Trigger Histamine Release in the Body
Alcohol and other fermented beverages	Dairy products (especially cheese)
Smoked or non-fresh seafood	(Dark) chocolate
Nuts (especially peanuts)	Eggplant (nightshade family)
Mango	Fermented foods (kimchi, pickled vegetables)
Mushrooms (shiitake, enoki, etc.)	Spices (e.g., curry)

 

The important information provided by Histamine Intolerance Analysis is as follows

• Evaluate if histamine levels are abnormal: Histamine comes from many everyday foods. Analyzing histamine levels in stool and assessing related clinical symptoms, while tracking the client’s dietary habits, will help determine whether there is a problem with histamine metabolism dysfunction.
• Evaluate DAO enzyme activity: Through testing, it can be determined whether the body has sufficient diamine oxidase (DAO) enzyme activity. This helps to assess whether abnormal histamine levels are due to enzyme dysfunction.
• Assess if IgE immune response is abnormal: Immunoglobulin E (IgE) is the main acute allergy marker in clinical practice. Elevated levels indicate that the individual is undergoing some degree of allergic reaction or inflammation. Histamine, a biologically active amine, is one of the main inflammatory mediators during immune reactions triggered by environmental allergens. It is primarily found in basophils, mast cells, chromaffin cells in the gastrointestinal tract, and lymph nodes. In addition to participating in immune responses, it stimulates gastric acid secretion, causes smooth muscle contraction, and dilates blood vessels, which is related to various allergic conditions and pseudo-allergic symptoms.
• Evaluate the exact cause and set a precise strategy: Analyzing histamine in stool, diamine oxidase, and immunoglobulin E to correctly distinguish whether the discomfort and related symptoms are caused by chronic food allergies or food intolerances is crucial for planning subsequent clinical strategies.