What is a gene variant?
Among all human DNA sequences, about 99% are identical from person to person. However, a small portion of the genetic sequence varies between individuals—and these small differences can be very important to human health. These subtle changes in the DNA sequence are called polymorphisms, and they can alter the shape or function of proteins, potentially affecting normal bodily functions. As a result, they may make you more susceptible to certain diseases—or, in some cases, more resistant.
If you carry a gene variant, it may increase your risk of developing certain chronic diseases, but it does not mean you will definitely get the disease. This is because your gene expression is not fixed—it can be influenced by many factors including environmental toxins, stress, sleep, exercise, diet, alcohol consumption, education level, and even personal relationships and romantic involvement.

Cardio Genomics^®

• APOE is involved in cholesterol and lipid transport. It is a key gene that determines serum levels of cholesterol and triglycerides.
• MTHFR is a crucial enzyme in folate metabolism. Polymorphisms in this gene can reduce enzyme activity, leading to impaired methylation and elevated homocysteine levels.
• eNOS polymorphisms can decrease the synthesis of nitric oxide (NO), increasing the risk of cardiovascular disease.
• AAGT, AGTR1, and AGTR2 genes regulate the production of vasoconstrictors in the body. These vasoconstrictors are hormones that stimulate smooth muscle contraction and promote sodium and water retention, thereby influencing blood pressure. Individuals with gene variants may be especially sensitive to salt intake, making them more prone to fluid and sodium retention and, consequently, hypertension.
• ACE polymorphisms are closely associated with the concentration of plasma angiotensin, affecting vascular tone and blood pressure regulation.
• PON-1 ( Paraoxonase-1)  is a hydrolytic enzyme carried in the blood by high-density lipoprotein (HDL). It serves as an effective biomarker for assessing cardiovascular disease risk.

Important insights provided by Genomics® include

• Understanding your inherent susceptibility
  Specific genetic polymorphisms may influence your risk for certain diseases.
• Cardiovascular gene analysis
  Helps identify predispositions to conditions such as hypercholesterolemia, myocardial infarction, atherosclerosis, stroke, endothelial dysfunction, hypertension, and Alzheimer’s disease.
• Risk reduction
  With tailored recommendations on diet, environment, lifestyle habits, nutritional supplements, and medical support, you can optimize your genetic potential for better health outcomes.
• Follow-up evaluation
  Based on potential biochemical imbalances and clinical needs, additional follow-up testing can be recommended for ongoing health monitoring.